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Targeted Tubulysin B Hydrazide Conjugate for the Treatment.

Targeted Tubulysin B Hydrazide Conjugate for the Treatment of Luteinizing Hormone-Releasing Hormone Receptor-Positive Cancers Jyoti Roy † ‡, Miranda Kaake ‡, Madduri Srinivasarao † ‡, and Philip S Low * † ‡

A targeted tubulysin B hydrazide conjugate for the.

Mar 05, 2018 · title = "A targeted tubulysin B hydrazide conjugate for the treatment of LHRH receptor-positive cancers.", abstract = "The targeted delivery of chemotherapeutic agents to receptors that are over-expressed on cancer cells has become an attractive strategy to concentrate drugs in cancer cells while avoiding uptake by healthy cells.

A targeted tubulysin B hydrazide conjugate for the.

Request PDF on ResearchGateOn May 31, 2018, jyoti roy and others published A targeted tubulysin B hydrazide conjugate for the treatment of LHRH receptor-positive cancers Targeted Tubulysin B Hydrazide Conjugate for the Treatment. That these complete responses are LHRH-R targeted was then established by showing that identical treatment of receptor-negative (SKOV3) tumors yields no antitumor response. Overall, these data provide a proof-of-concept that LHRH-R specific targeting of an extremely toxic drug like tubulysin B can treat LHRH-R positive tumors without causing.Development of a Small Molecule Tubulysin B Conjugate for. A small molecule CAIX-targeted tubulysin B conjugate was then synthesized and examined for its ability to kill CAIX-expressing tumor cells in vitro. Potent therapeutic conjugates were subsequently tested in vivo and demonstrated to eliminate solid human tumor xenografts in murine tumor models without exhibiting overt signs of toxicity.PSMA-targeted tubulysin B-containing conjugate EC1169. PSMA-targeted tubulysin B-containing conjugate EC1169. Upon administration of PSMA-targeted tubulysin B-containing conjugate EC1169, the PSMA ligand specifically targets and binds to PSMA, a protein which is abundantly expressed on the surface of metastatic and hormone-refractory prostate cancer cells as well as on the neovasculature.Definition of PSMA-targeted tubulysin B-containing. PSMA-targeted tubulysin B-containing conjugate EC1169 An injectable, water soluble, small molecule drug conjugate (SMDC) containing a ligand specific for prostate-specific membrane antigen (PSMA), conjugated via a stable, enzyme-cleavable linker to the cytotoxic agent tubulysin B hydrazide (TubBH), with potential antineoplastic activity.

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